GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs1451375 | 1 | rs4452748 | chr7:50625056 | FIGNL1 | chr7:50511834-50518088:- | 0.17 | 4.36 | 1.61E-5 | Malaria |
| THCA | cis | rs10760706 | 1 | rs4452862 | chr9:102706745 | STX17 | chr9:102668915-102736817:+ | -0.17 | -4.33 | 1.86E-5 | Alopecia areata |
| THCA | cis | rs3136441 | 1 | rs4453193 | chr11:46787406 | DDB2 | chr11:47236493-47260769:+ | 0.22 | 3.48 | 0.000544 | HDL cholesterol |
| THCA | cis | rs3136441 | 1 | rs4453193 | chr11:46787406 | ZNF408 | chr11:46722368-46727461:+ | -0.19 | -3.61 | 0.000338 | HDL cholesterol |
| THCA | cis | rs4453791 | 1 | rs4453791 | chr3:38882519 | WDR48 | chr3:39093507-39138149:+ | 0.28 | 3.65 | 0.000287 | Social communication problems |
| THCA | cis | rs7225151 | 1 | rs4456560 | chr17:5140399 | C17orf87 | chr17:5113901-5138083:- | 0.16 | 3.68 | 0.000258 | Alzheimer's disease (late onset) |
| THCA | cis | rs7225151 | 1 | rs4456560 | chr17:5140399 | SPNS2 | chr17:4402129-4443228:+ | 0.19 | 3.92 | 9.95E-5 | Alzheimer's disease (late onset) |
| THCA | cis | rs7225151 | 1 | rs4456560 | chr17:5140399 | ZNF232 | chr17:5008839-5026397:- | -0.29 | -3.81 | 0.000155 | Alzheimer's disease (late onset) |
| THCA | cis | rs4459386 | 1 | rs4459386 | chr12:50594947 | C12orf62 | chr12:50505900-50514234:+ | 0.11 | 4.28 | 2.26E-5 | Schizophrenia |
| THCA | cis | rs12216499 | 1 | rs4460230 | chr6:159369990 | RSPH3 | chr6:159398268-159421198:- | 0.28 | 6 | 3.97E-9 | Bladder cancer (smoking interaction) |
| THCA | cis | rs6499255 | 1 | rs4464069 | chr16:69816284 | COG4 | chr16:70514473-70557457:- | -0.22 | -4.41 | 1.26E-5 | IgE levels |
| THCA | cis | rs138777 | 1 | rs4465 | chr22:35708790 | HMGXB4 | chr22:35653445-35691799:+ | -0.11 | -3.35 | 0.000887 | Cholesterol, total |
| THCA | cis | rs9902453 | 1 | rs4465649 | chr17:28394747 | ANKRD13B | chr17:27916801-27941778:+ | -0.36 | -8.96 | 7.37E-18 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4465649 | chr17:28394747 | CORO6 | chr17:27941774-27948441:- | -0.5 | -11.6 | 1.33E-27 | Coffee consumption (cups per day) |
| THCA | cis | rs9902453 | 1 | rs4465649 | chr17:28394747 | EFCAB5 | chr17:28256874-28435469:+ | -0.59 | -11.24 | 3.52E-26 | Coffee consumption (cups per day) |